导师简介
王一兵
1.个人基本信息
王一兵，ok138cn太阳集团古天乐副教授，主要研究新基因调控运动改善肝脏代谢机制，新靶点药物发现以及基于腺相关病毒的基因治疗脂肪肝等。目前为止共发表学术论文36篇 , 其中SCI论文35篇。其中以第一作者(含共同第一)， 通讯作者(含共同通讯)等身份发表
Nature Communications (IF2025=15.7, 中科院1区顶刊);
Molecular Cell (IF2025=16.6,中科院1区顶刊);
Pharmacological Research (IF2025=10.5,中科院2区顶刊);
Journal of Genetics and Genomes (IF2025=7.1,中科院1区顶刊);
Genes & Diseases (IF2021=7.243, 中科院2区顶刊)
等国际SCI期刊上22篇。
担任 Metabolism Open, Cell Reports Medicine, Acta Pharmaceutica Sinica等国际期刊的审稿专家。讲授本科课程《人体生理学》，《运动生理学》，《运动生理学实验》，《生理学实验》。讲授研究生课程《体育科学研究方法》和《运动科学前沿讲座》。
专长：有机化学，生物化学，遗传学，腺相关病毒AAV研究
联系方式：wangyibing@sus.edu.cn. 移动电话：18310860190
2. 教育 和工作经历
2000年9月-2004年7月 复旦大学化学系 理学学士
2004年9月-2009年7月 中国科学院上海有机化学研究所 有机化学 理学博士
2009年8月-2009年11月 中国科学院上海有机化学研究所 研究助理
2010年11月-2013年12月 美国德州大学西南医学中心UT Southwestern Medical
Center at Dallas生物化学系 博士后
2014年 1月-2016年11月 美国德州大学西南医学中心UT Southwestern Medical
Center at Dallas生物化学系 博士后
2016年12月-2017年12月 美国德州大学西南医学中心UT Southwestern Medical
Center at Dallas生物化学系 研究科学家
2018年1月-2021年1月 北京生命科学研究所 遗传筛选中心主任
2021年1月-至今 上海体育大学 教师
3. 学术成果 （按距今时间倒序）
(36) Wang, Y#.; Peng, J. (#: Corresponding author) Proteolysis targeting chimera degraders target pseudokinases to treat metabolic dysfunction-associated steatohepatitis and fibrosis: Mechanisms and therapeutic insights. Pharmacol Res. 2025, 222, 108054 (in press)
(35) Wang, Y#.; Wan, S. (#: Corresponding author) Mitochondrial MFN2 integrates the function of multiple organelles to regulate metabolic dysfunction-associated steatotic liver disease: Mechanisms and therapeutic insights. Biochem Pharmacol. 2025, 242, 117423.
(34) Peng, J.; Wang, Y#. (#: Corresponding author) TRIB3 at the nexus of metabolic disorders: In-depth analysis of biochemical mechanisms and concepts for drug discovery. Biochem Pharmacol. 2025, 240, 117108.
(33) Lin, Y.; Wang, Y#. (#: Corresponding author) Orphan GPCRs regulate the metabolic liver diseases through mediating the crosstalk between the liver and immune cells: Mechanisms and therapeutics. Eur J Med Chem. 2025, 297, 117906.
(32) Zu, Y.; Wu, C.; Li, F.; Yao, H.; Xia, Y.; Zhang, R.; Li, L.; Chen, S.; Shi, Q.; Xi, S.; Pang, H.; Liu, M.; Wang, L.; Terpack, S.; Wang, W.; Chen, S.; Zhang, H.; Wang, Y.; Yang, M.; Huang, S.; Zhou, F.; Tang, Y.; Hu, Z.; Fan, S.; Tang, Y.; Lee, Y.S.; Wang G. The NAMPT enzyme employs a switch that directly senses AMP/ATP and regulates cellular responses to energy stress. Mol. Cell. 2025, 85, 2271-2286.
(31) Wang, D.; Wang, Y.#. (#: Corresponding author) Identification of protein partners for small molecules reshapes the understanding of nonalcoholic steatohepatitis and drug discovery. Life Sci. 2024, 356, 123031.
(30) 林小晶，付绍婷， 杨宏芳，王一兵，王晓慧. 有氧运动通过降低chemerin改善肥胖，糖尿病和动脉粥样硬化大鼠血糖血脂及其机制的研究。中国康复医学杂志，2024年11期，1561-1571.
(29) Xing, X.; Sun, Q.; Wang, R.; Wang, Y#.; Wang, R#. (#: Co-corresponding authors) Impacts of glutamate, an exercise-responsive metabolite on insulin signaling. Life Sci. 2024, 341, 122471.
(28) Wang, Y#.; Zheng, J.; Long, Y.; Wu, W.; Zhu, Y. (#: Corresponding author) Direct degradation and stabilization of proteins: New horizons in treatment of nonalcoholic steatohepatitis. Biochem Pharmacol. 2024, 220, 115989.
(27) Sun, Q.; Xing, X.; Wang, H.; Wan, K.; Fan, R.; Liu, C.; Wang, Y.; Wu, W.; Wang, Y#.; Wang, R#. (#: Co-corresponding authors) SCD1 is the critical signaling hub to mediate metabolic diseases: Mechanism and the development of its inhibitors. Biomed Pharmacother. 2024, 170, 115586.
(26) Zheng, J.; Wang R.#; Wang, Y#. (#: Co-corresponding authors) New concepts drive the development of delivery tools for sustainable treatment of diabetic complications. Biomed Pharmacother. 2024, 171, 116206.
(25) Bian, X.; Wang, Q.; Wang, Y#.; Lou, S#. (#: Co-corresponding authors) The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases. Front Mol Neurosci. 2024, 16, 1305208.
(24) Wang, Y#.; Yu, H.; Cen, Z.; Zhu, Y.; Wu, W. (#: Corresponding author) Drug targets regulate systemic metabolism and provide new horizons to treat nonalcoholic steatohepatitis. Metabol Open. 2023, 14, 100267.
(23) Wu, W.; Zheng, J.; Wang, R#.; Wang, Y#. (#: Co-corresponding authors) Ion channels regulate energy homeostasis and the progression of metabolic disorders: Novel mechanisms and pharmacology of their modulators. Biochem Pharmacol. 2023, 218, 115863.
(22) Chen, L.; Wang, Y#. (#: Corresponding author) Interdisciplinary advances reshape the delivery tools for effective NASH treatment. Mol Metab. 2023, 73, 101730.
(21) Wang, Y#. (#: Corresponding author) Multidisciplinary Advances Address the Challenges in Developing Drugs against Transient Receptor Potential Channels to Treat Metabolic Disorders. ChemMedChem. 2023, 18, e202200562.
(20) Wang, R.; Sun, Q.; Wu, X.; Zhang, Y.; Xing, X.; Lin, K.; Feng, Y.; Wang, M.; Wang, Y#.; Wang, R#. (#: Co-corresponding authors) Hypoxia as a Double-Edged Sword to Combat Obesity and Comorbidities. Cells. 2022, 11, 3735.
(19) Li, Y.; Xu, J.; Guo, X.; Li, Z.; Cao, L.; Liu, S.; Guo, Y.; Wang, G.; Luo, Y.; Zhang, Z.; Wei, X.; Zhao, Y.; Liu, T.; Wang, X.; Xia, H.; Kuang, M.; Guo, Q.; Li, J.; Chen, L.; Wang, Y.; Li, Q.; Wang, F.; Liu, Q.; You, F. The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model. Genome Biol. 2023, 24, 20.
(18) Xie, L.; Yuan, Y.; Xu, S.; Lu, S.; Gu, J.; Wang, Y.; Wang, Y.; Zhang, X.; Chen, S.; Li, J.; Lu, J.; Sun, H.; Hu, R.; Piao, H.; Wang W.; Wang, C.; Wang, J.; Li, N.; White, M.F.; Han L, Jia, W.; Miao, J.; Liu J. Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex. Cell Rep. 2022, 41, 111498.
(17) Wang, G.; Li, Q.; Xu, J.; Zhao, S.; Zhou, R.; Chen, Z.; Jiang, W.; Gao, X.; Zhou, S.; Chen, Z.; Sun, Q.; Ma, C.; Chen, L.; Shi, B.; Guo, Y.; Wang, H.; Wang, X.; Li, H.; Cai, T.; Wang, Y.; Chen, Z.; Wang, F.; Liu, Q. Somatic genetics analysis of sleep in adult mice. J Neurosci. 2022, 42(28):5617-5640.
(16) Liu, N.; Tian, H.; Yu, Z.; Zhao, H.; Li, W.; Sang, D.; Lin, K.; Cui, Y.; Liao, M.; Xu, Z.; Chen, C.; Guo, Y.; Wang, Y.; Huang, HW.; Wang, J.; Zhang, H.; Wu, W.; Huang, H.; Lv, S.; Guo, Z.; Wang, W.; Zheng, S.; Wang, F.; Zhang, Y.; Cai, T.; Zhang, EE. Cell Rep. 2022, 39(7):110816.
(15) Zhang, T.; Zhao, J.; Liu, T.; Cheng, W#.; Wang, Y#.; Ding, S#.; Wang, R#. (#: Co-corresponding authors) A novel mechanism for NLRP3 inflammasome activation. Metabolism Open 2022, 13, 100166
(14) Wang, Y.; Xiong, J.; Yuan, Y.; Peng, C.; Wu, P.; Wang, Y.; Lu, J.; Yin, Y.; Xu, J.; Chen, S.; Liu, J. Suppression of RIP1 activity via S415 dephosphorylation ameliorates obesity-related hepatic insulin resistance. Obesity (Silver Spring). 2022, 30(3):680-693
(13) Lu, S.; Wang, Y#.; Liu, J#. Tumor necrosis factor-α signaling in nonalcoholic steatohepatitis and targeted therapies. (#: Co-corresponding authors) J Genet Genomics. 2022, 49(4):269-278.
(12) Zhang, Y.; Wang, Y#.; Liu, J#. Friend or foe for obesity: how hepatokines remodel adipose tissues and translational perspective. (#: Co-corresponding authors) Genes & Diseases. 2022, 10, 825-847.
(11) Wei, G.; Sun, H.; Dong, K.; Hu, L.; Wang, Q.; Zhuang, Q.; Zhu, Y.; Zhang, X.; Shao, Y.; Tang, H.; Li, Z.; Chen, S.; Lu, J.; Wang, Y.; Gan, X.; Zhong, T.; Gui, D.; Hu, X.; Wang, L.; Liu, J. The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy. Cell Metab. 2021, 33(10):2021-2039.e8.
(10) Wang, Y#.; Cao, L#.; Lee, CY#.; et al Kobayakawa, K.; Beutler, B.; Liu, Q*. (#: co-first authors) Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors. Nat. Commun. 2018, 9, 2041
(9) Liang, C#.; Wang, Y#.; Murota, Y.; Liu, X.; Smith, D.; Siomi, M.; Liu, Q*. (#: co-first authors) TAF11 assembles the RISC loading complex to enhance RNAi efficiency. Mol. Cell. 2015, 59, 807-818
(8) Egerod, K*.; Petersen, N.; Timshel, P.; Rekling, J.; Wang, Y.; Liu, Q.; Schwartz, T.; Gautron, L*. Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms. Mol. Metab. 2018, 12, 62-75
(7) Leon Mercado, L#.; Caron, A#.; Wang, Y.; Burton, M.; Gautron, L*. (#: co-first authors) Identification of Leptin receptor-expressing cells in the nodose ganglion of male mice. Endocrinology. 2019, 160, 1307-1322.
(6) Zheng, S*.; Wang, Y.; Liu, H.; Chang, W.; Xu, Y.; Lin, F*. Prediction of hemolytic toxicity for saponins by machine-learning methods. Chem. Res. Toxicol. 2019, 32, 1014-1026.
(6) Zheng, S*.; Wang, Y.; Liu, W.; Chang, W.; Liang, G.; Xu, Y.; Lin, F*. In Silico prediction of hemolytic toxicity on the human erythrocytes for small molecules by machine-learning and genetic algorithm. J. Med. Chem. 2020, 63, 6499-6512.
(4) Zheng, S*.; Xiong, J.; Wang, Y.; Liang, G.; Xu, Y.; Lin, F*. Quantitative prediction of hemolytic toxicity for small molecules and their potential hemolytic fragments by machine learning and recursive fragmentation methods. J. Chem. Inf. Model. 2020, 60, 3231-3245.
(3) Wang, Y.; Zhang, Y.; Zhu, Z.; Zhu, S.; Li, Y.; Li, M.; Yu, B*. Exploration of the correlation between the structure, hemolytic activity, and cytotoxicity of steroid saponins. Bioorg. Med. Chem. 2007, 15, 2528-2532
(2) Wang, Y.; Zhang, Y.; Yu, B*. The cytotoxicity of saponins correlates with their cellular internalization. ChemMedChem. 2007, 2, 288-291
(1) Li, W.; Qiu, Z.; Wang, Y.; Zhang, Y.; Li, M.; Yu, J.; Zhang, L.; Zhu, Z.; Yu, B*. Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives. Carbohydr. Res. 2007, 342, 2705-2715
